Isaac prayed that his wife Rebekah have a child, and she had twins, Esau and Jacob. Jacob was born grasping Esau’s heel, which is prophetic given how he would later contend with God, and references to this can be seen in Hosea 12 and Micah 1. Jacob convinces Esau to give away his birthright in a moment of hunger.
When a famine fell upon the land, Jacob went to Gerar, and Abimelech, the king. God told Isaac not to journey to Egypt, so he remained in Gerar. Isaac became rich, and Abimelech sent him away.